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. Author manuscript; available in PMC: 2011 Feb 2.

Published in final edited form as: Brain Struct Funct. 2010 Mar 7;214(2-3):161–179. doi: 10.1007/s00429-010-0245-1

Table 3.

Dendrite and spine morphometry from layer III pyramidal neurons from the PFC of htau mice during disease progression

Age (months)	Morphology (μm)		Spine
			Density (spines/μm)		Type (%)
	Apical	Basal	Apical	Basal	Apical
					S	T	M
3	1,338.6 ± 123.8	359.0 ± 26.4	1.40 ± 0.06	1.62 ± 0.11	28.42 ± 1.34	43.5 ± 3.59 ^*	27.81 ± 2.11
6	1,330.0 ± 94.4	369.7 ± 22.6	1.70 ± 0.06	1.83 ± 0.08	25.44 ± 1.27 ^**	54.58 ± 2.52 ^*	20.0 ± 2.97
12	1,429.5 ± 31.7	411.1 ± 28.8	1.96 ± 0.09 ^**	1.80 ± 0.07	31.92 ± 1.04 ^**	49.65 ± 1.86	18.45 ± 1.14

Age (months)	Spine
	Type (%)			Volume (μm³)
	Basal			Apical			Basal
	S	T	M	S	T	M	S	T	M
3	26.51 ± 1.25	45.56 ± 2.97 ^*	27.88 ± 1.77 ^*	0.111 ± 0.03	0.038 ± 0.002	0.218 ± 0.02	0.088 ± 0.01 ^**	0.031 ± 0.002 ^*	0.203 ± 0.01
6	23.45 ± 1.27 ^**	56.12 ± 2.21 ^*	20.44 ± 1.62 ^*	0.069 ± 0.004	0.044 ± 0.002	0.209 ± 0.01	0.061 ± 0.004 ^**	0.037 ± 0.001	0.174 ± 0.01 ^**
12	29.96 ± 1.52 ^**	49.4 ± 1.57	20.64 ± 0.85	0.08 ± 0.002	0.047 ± 0.003	0.252 ± 0.01	0.065 ± 0.001	0.043 ± 0.001 ^*	0.222 ± 0.01 ^**

S stubby spine, T thin spine, M mushroom spine

^*

p<0.05,

^**

p<0.01