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. Author manuscript; available in PMC: 2011 Aug 1.

Published in final edited form as: J Viral Hepat. 2009 Nov 2;17(8):588–597. doi: 10.1111/j.1365-2893.2009.01214.x

Table 2.

PreSurface (PreS) and surface (S) mutations. S open reading frame mutations identified in Occult hepatitis B virus-infected individuals

Surface region	HBV genotype	Newly identified		Previously identified	Reference
PreS1	A	N98Y
	A	S109P
	G	M1I	D41N
		G2R	P88L
		L3I	A89T
		S4P	P93L
		W5R	R102G
		S16P	T105I
		F23S	P106S
		D26Y
PreS2	A	S28G
		H41Q
		D51G
	G	L20P
	G	T37A
Surface	A	Y72H
		I82T		G145A ^†	[21]
		A128T^†
	E	Y100F^†		F85C	[24]
				Y100S^†	[24]
				G145R^†	[18,22]
	G	S55P
		P62L
		F80S
		I86V
		L95W
		S136P^†

Mutations also identified in the signature sequence analysis are indicated in bold.

^†

Mutations that reside within the antigenic determinant loops of hepatitis B surface antigen (AA 100–165).