Table V.
RD, ED, Recovery (%), Emission (%), Impaction Loss, MMAD, GSD and FPF of Salbutamol Sulphate from Different Formulation Blends (Mean ± SD, n = 3)
| Lactose product formulations | RD (μg) | ED (μg) | Recovery (%) | Emission (%) | Impaction loss (%) | MMAD (μm) | GSD | FPF (%) |
|---|---|---|---|---|---|---|---|---|
| Commercial lactose | 317 ± 5 | 299 ± 7 | 65.9 ± 1.1 | 94.5 ± 0.6 | 67.8 ± 4.7 | 3.2 ± 0.4 | 2.2 ± 0.1 | 19.7 ± 1.9 |
| Crystallised using ethanol | 400 ± 5 | 380 ± 5 | 83.2 ± 1.0 | 95.0 ± 0.1 | 55.6 ± 6.4 | 3.2 ± 0.1 | 2.2 ± 0.0 | 28.9 ± 5.6 |
| Crystallised using ethanol/butanol (60:20) | 419 ± 13 | 403 ± 13 | 87.1 ± 2.6 | 96.1 ± 0.3 | 51.8 ± 4.0 | 3.2 ± 0.1 | 2.1 ± 0.0 | 32.1 ± 2.6 |
| Crystallised using ethanol/butanol (40:40) | 398 ± 16 | 383 ± 14 | 82.7 ± 3.3 | 96.3 ± 0.4 | 56.1 ± 5.1 | 3.6 ± 0.0 | 2.1 ± 0.0 | 27.3 ± 3.6 |
| Crystallised using ethanol/butanol (20:60) | 405 ± 39 | 381 ± 42 | 84.1 ± 8.1 | 94.1 ± 1.2 | 40.0 ± 3.6 | 3.4 ± 0.0 | 2.1 ± 0.1 | 38.0 ± 2.5 |
| Crystallised using butanol | 393 ± 40 | 372 ± 40 | 81.6 ± 8.2 | 94.8 ± 0.6 | 49.2 ± 3.1 | 2.9 ± 0.0 | 2.2 ± 0.0 | 35.4 ± 2.5 |
RD recovered dose, ED emitted dose, MMAD mass median aerodynamic diameter, GSD geometric standard deviation, FPF fine particle fraction