Fig. 5.
Effects of intra-NAC 5-HT2C blockade with SB 242084 upon the acute and sensitized locomotor response to cocaine. a Summary of the effects of 0, 50, 100 and, 500 nM of the 5-HT2C antagonist SB 242084 administered into the NAC upon the time-course of locomotor hyperactivity elicited by an acute injection of 15 mg/kg cocaine, administered 3 weeks following repeated saline treatment. b Summary of the effects of intra-NAC SB 242084 upon the time-course of locomotion elicited by a 15 mg/kg cocaine challenge injection, administered 3 weeks following repeated cocaine treatment. *p < 0.05 for 0 nM-Cocaine vs. respective Saline; **p < 0.05 for both 0 & 50 nM-Cocaine vs. respective Saline groups (sensitization); +p < 0.05 for 500 nM vs. respective 0 nM pretreatment; ++p < 0.05 for both 100 and 500 nM vs. respective 0 nM pretreatment; +++p < 0.05 for 50, 100 and 500 nM vs. respective 0 nM pretreatment. c Effect of intra-NAC MDL 100907 upon the total distance traveled during the 2-h test session by repeated saline- and cocaine-treated rats. *p < 0.05 Cocaine vs. Saline (sensitization); +p < 0.05 vs. 0 nM (pretreatment effect). The data represent the mean ± SEM of the number of animals indicated in parentheses