Fig. 6.

Effects of intra-NAC 5-HT_2C blockade with SB 242084 upon cocaine-induced neurochemical sensitization. a Summary of the effects of perfusing the NAC, via the microdialysis probe, with 0, 50, or 100 nM of the 5-HT_2C antagonist SB 242084 upon the time-course of changes in extracellular dopamine elicited by a 15-mg/kg cocaine challenge injection, administered 3 weeks following repeated saline/cocaine treatment. b Data from a expressed as a percent change from the average baseline values. c AUC for the cumulative data in b. d Summary of the effects of perfusing the NAC with SB 242084 upon the time-course of changes in extracellular glutamate elicited by the 15 mg/kg cocaine challenge. e Data from d expressed as a percent change from the average baseline glutamate values. f AUC for the cumulative data in e. For all panels, saline-treated animals are represented by open symbols, and cocaine-treated animals are represented by closed symbols. The data represent the mean ± SEM of the number of animals indicated in parentheses. For panels a, b, d, e, *p < 0.05 for 0 nM-Cocaine vs. respective Saline (cocaine effect/sensitization); +p < 0.05 for 100 nM vs. respective 0 nM pretreatment; ++p < 0.05 for both 50 and 100 nM vs. respective 0 nM pretreatment. For c and f: *p < 0.05 for saline vs. cocaine (cocaine effect/sensitization); +p < 0.05 for 50 or 100 nM vs. 0 nM pretreatment