Figure 3.

The architecture design underlying the CytoSolve method employs a dynamic messaging approach to manage and integrate communications across a distributed ensemble of D models based on instructions by the GUI at the Presentation layer. The Controller layer integrates the solution among the models using three components: Monitor, Comm Mgr and Mass Balance. The Communication layer provides infrastructure to communicate input and output values across models running as separate processes on a single server or separately on individual servers. The Data Base layer provides storage for the Solution to hold the results of the integrated and individual model solutions along with Ontology for registering and describing each model’s characteristics and annotations made by the user. The Models layer denotes the ensemble of models, which may be remote or local