Figure 3.
Protein levels of TNF, CCL2, and CCL20 in whole lung homogenates in mice challenged with Aspergillus. (A–C) Cytokine levels in animals with Ab-mediated neutrophil depletion with RB6-8C5 or isotype control mAb were measured at various times following challenge with killed hyphae. Day 0 represents unchallenged mice. Data represent mean ± SEM of pooled data from 2 experiments; n = 6–8 mice per group per time point. *, p < 0.05 comparing trend between the two groups over time. (D) Lung cytokine levels in mice with with Ab-mediated neutrophil depletion with 1A8 or isotype control mAb on day 1 after challenge with with killed hyphae. Data represent mean ± SEM; n = 10 mice per group. *, p < 0.05 compared to non-neutropenic group.