Application of clinical trial information to clinical care.

Based on available studies, the clinician should anticipate that variability to response will occur with each treatment, that this variability in response can be associated with patient characteristics, biomarkers and genetics, and that response to treatment should be monitored for the various outcomes measures, especially symptom control and pulmonary function to assure rapid and sustained achievement of asthma control. Reproduced with permission from Szefler SJ and Martin RJ. Lessons learned from variation in response to therapy in clinical trials. J Allergy Clin Immunol 2010;125:285–92.