Table 3.
BQTN analysis of SNPs in HTR5A proximity
| SNP | Chr7 Position† | Location | P Value of Association Analysis | Posterior Probability (BQTN) | |
|---|---|---|---|---|---|
| rs6972688 | 154260597 | upstream | 0.3383 | NS | |
| rs7805887 | 154261124 | upstream | 0.3357 | NS | |
| rs1583830 | 154273658 | upstream | 0.9240 | NS | |
| rs4960675 | 154278282 | upstream | 0.2459 | NS | |
| rs4960575 | 154283439 | upstream | 0.9166 | NS | |
| rs1440461 | 154287271 | upstream | 0.6806 | NS | |
| rs1440458 | 154291802 | upstream | 0.0184 | NS | |
| rs1440454 | 154294985 | upstream | 0.7459 | NS | |
| rs2873379* | 154297883 | upstream | 0.0005 | ||
| rs1017488* | 154297955 | upstream | 0.0011 | ||
| rs2698501* | 154298339 | upstream | 0.0003 | ||
| −1910G_A* | 154298348 | upstream | 0.0333 | NS | |
| −1457T_C* | 154298801 | upstream | 0.2060 | NS | |
| rs1881691* | 154299041 | upstream | 0.0019 | ||
| −1015A_G* | 154299243 | upstream | 0.9825 | NS | |
| rs3823534* | 154299836 | upstream | 0.0029 | ||
| rs3734966* | 154300082 | upstream | 0.6481 | NS | |
| rs3734967* | 154300156 | upstream | 0.0016 | 0.59 | |
| rs1800883* | 154300239 | upstream | 0.2819 | NS | |
| HTR5A starts | 154300258 | ||||
| rs6320* | 154300269 | exon | 0.0028 | ||
| 42T_C* | 154300300 | exon | 0.0635 | NS | |
| rs2241859* | 154301115 | intron | 0.0165 | NS | |
| 862G_A* | 154301120 | intron | 0.3144 | NS | |
| rs2581841* | 154301487 | intron | 0.0072 | ||
| rs4581000 | 154307991 | intron | 0.0521 | NS | |
| rs6597455 | 154309013 | intron | 0.0035 | ||
| rs732050 | 154311043 | intron | 0.0101 | NS | |
| rs2698512 | 154312220 | intron | 0.6632 | NS | |
| rs1657268 | 154312262 | intron | 0.2035 | NS | |
| rs6947679 | 154313114 | intron | 0.3617 | NS | |
| rs1730208 | 154313428 | intron | 0.0245 | NS | |
| rs893112 | 154317886 | downstream | 0.0246 | NS | |
| rs1657278 | 154322472 | downstream | 0.0247 | NS | |
| rs1730135 | 154322733 | downstream | 0.0312 | NS | |
| rs1436818 | 154322885 | downstream | 0.0302 | NS | 0.97 |
| rs1730182 | 154327796 | downstream | 0.0116 | NS | 0.97 |
| rs893109 | 154330522 | downstream | 0.0094 | ||
| rs1730143 | 154333441 | downstream | 0.1116 | NS | |
| rs1657265 | 154335681 | downstream | 0.0161 | NS | |
| rs893108 | 154371096 | downstream | 0.0258 | NS |
*
SNPs revealed by resequencing in 47 unrelated individuals of the Metabolic Risk Complications of Obesity Genes (MRC-OB) cohort. BQTN, Bayesian quantitative trait nucleotide.
†
Based on build 125. NS, nonsignificant association between SNP and TG level (P > 0.01).