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. 2010 Feb 18;1(2):e26. doi: 10.1038/cddis.2010.2

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Copyright © 2010 Macmillan Publishers Limited

This article is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 license. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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CaspaTag staining of saponin-enriched Plasmodium falciparum parasites shows the activation of cysteine proteases after incubation with drugs. (a) Percentage of CaspaTag-positive cells pretreated with vehicle control, 10 μM 4-hydroxytamoxifen (4HT) or 50 μM z-VAD-fmk (zVAD) and subjected to 8 h treatment with vehicle control , 30 μM chloroquine or 10 μM of staurosporine . In each experiment, the full set of treatment conditions were carried out concurrently with the same batch of cells. Data represent means±S.E. (AvB, AvC, BvG, AvD, CvF and BvE, P<0.001; N=3) (b) Fluorescent microscopy and (c) flow cytometry histograms show the increase in proportion of CaspaTag-positive cells after chloroquine treatment, with and without 30 min preincubation with zVAD or 4HT

Inline graphic — CaspaTag staining of saponin-enriched Plasmodium falciparum parasites shows the activation of cysteine proteases after incubation with drugs. (a) Percentage of CaspaTag-positive cells pretreated with vehicle control, 10 μM 4-hydroxytamoxifen (4HT) or 50 μM z-VAD-fmk (zVAD) and subjected to 8 h treatment with vehicle control , 30 μM chloroquine or 10 μM of staurosporine . In each experiment, the full set of treatment conditions were carried out concurrently with the same batch of cells. Data represent means±S.E. (AvB, AvC, BvG, AvD, CvF and BvE, P<0.001; N=3) (b) Fluorescent microscopy and (c) flow cytometry histograms show the increase in proportion of CaspaTag-positive cells after chloroquine treatment, with and without 30 min preincubation with zVAD or 4HT