Table 3.

Regions identified in the whole brain analysis where control and depressed subjects significantly differed in their associations between rCBF and cardiac autonomic indices. The region name and sterotaxic coordinates of each cluster maxima are given, as well as other voxels remaining significant after applying voxel-wise corrections for multiple testing within and outside significant clusters. Regression coefficients from the general linear model are given, with the larger regression coefficient shown in boldface.

Autonomic Index	Regresson Coefficient Healthy	Regression Coefficient MDD	Task	Region	Voxel Z	Talairach coordinated
HR	0.3167	−0.1229	NBack	Lateral Superior Frontal Gy	5.00a,b	−18 28 56
	0.3293	−0.1296		Superior Parietal C	5.28b	−30 −66 46
	−0.1493	0.0772		Dorsomedial Superior Frontal Gy	4.58c	−12 −17 43
	−0.3485	0.1067		Parieto-Occipital C	5.20b	20 −72 44
	−0.3004	0.1112	Handgrip	Precentral Gy	4.85b,c	48 2 40
InHF	−1.5069	1.032	NBack	Lingual Gy	3.72c	8 −56 1
InLF	−1.8206	0.4887	Handgrip	Cerebellum, Declive	4.18a	−44 −66 −17
	2.4199	−0.6527	NBack	Brainstem, Pons	4.23a	−16 −34 −33
LF/HF	0.2254	−0.6262	Handgrip	Medial Orbitofrontal C (BA 10r)	4.85b,c	4 44 −22
	0.1787	−0.8616	Nback	Temporal Polar Cortex	4.69a	46 −21 −28
RMSSD	0.1351	−0.0450	Fix	Fusiform Gy	4.76b	−46 −47 −8
	0.1256	−0.0003	Nback	Ventrolateral PFC	3.94a	46 27 6
	−0.1157	0.0050		Medial Cerebellum	3.23a	−6 −67 −22

^asignificant at p≤0.05 after applying corrections for multiple comparisons using the cluster test

^bsignificant at p≤0.05 (family-wise error) after voxel-wise correction for multiple comparisons

^csignificant at p≤0.001 after applying corrections for multiple comparisons using the cluster test

^dStereotaxic coordinates and Abbreviations interpreted as in Table 2