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. 2011 Feb;137(2):155–172. doi: 10.1085/jgp.201010470

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© 2011 Hilgemann and Fine

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — Summary of changes of DPA signals in response to a single Ca influx episode and multiple Ca-dependent MEND protocols. Examples of each experiment type are presented in Figs. S12–S14. Each bar set gives give the average of three or more experiments for cell capacitance, DPA capacitance, and DPA currents, normalized to their initial experimental values (leftmost bar set). From left to right, Ca influx causes on average a threefold greater increase of DPA capacitance than cell capacitance, and a small increase of DPA current. After Ca influx, the presence of high ATP in the cytoplasm causes a return of DPA capacitance and current to baseline, whereas cell capacitance decreased to 50% below baseline. Polyamine/Ca-induced MEND causes on average an increase of DPA capacitance and current, whereas cell capacitance decreases to 55% below baseline. When cells are enriched with cholesterol, Ca influx without polyamines causes a 58% decrease of cell capacitance, whereas DPA capacitance and current decrease on averaged by 18 and 15%. Cholesterol enrichment after a Ca transient has increased cell capacitance by 25% results on average in a decrease of cell capacitance by 66%, whereas DPA capacitance and current remain 18 and 25% greater than baseline.