Table 1.
Network | Total N content, mmol/mg* | Hydrodynamic diameter, nm† | NTP content in Nano-NRTIs,%‡ |
|||
---|---|---|---|---|---|---|
AZTTP | ddITP | CTP | ||||
NG1 | PEG-cl-PEIss | 2.5 | 175 ± 10 (90 ± 3) | 23 | 8.5 | 13.5 |
NG2 | F68-cl-PEIss | 2.1 | 190 ± 7 (120 ± 9) | 16 | 6.5 | 11 |
NG3 | starPEG-g-PEI | 1.8 | 150 ± 9 (115 ± 5) | 21 | 11.5 | 15.5 |
NG4 | PAMAM-PEI-g-PEG | 2.2 | 160 ± 7 (100 ± 6) | 12 | 5.5 | 13 |
AP-NG1 | ApoE-NG1 | 1.9 | 197 ± 11 (105 ± 5) | 16 | 8 | 9.5 |
Determined by elemental analysis of nanogels
Measured by DLS (water, pH 7, concentration 0.1%). Data for NTP-loaded nanogels are shown in brackets
Determined by UV absorbance of aqueous solutions of NTP-loaded nanogels and free drugs at 260 nm