Table 2.

Models of Crude Hazard Ratios of Ischemic Stroke by WML and Blood Pressure (per 1 mmHg)

Univariable models
Model	Predictor	HR	95% CI (p)*
1	WML	2.920	2.277–3.748 (<.001)
2	DBP	1.019	1.007–1.031 (.002)
3	SBP	1.017	1.011–1.022 (<.001)
4	PP	1.016	1.009–1.023 (<.001)
5	DBP	1.015	1.005–1.026 (.005)
	DBP2	1.001	1.000–1.001 (.002)
6	SBP	1.013	0.948–1.051
	SBP2	1.000	1.000–1.000
7	PP	1.018	1.004–1.031 (.010)
	PP2	1.000	1.000–1.000
Bivariable models
1	DBP	1.016	1.004–1.028 (.007)
	WML	2.874	2.240–3.690 (<.001)
2	SBP	1.014	1.008–1.020 (<.001)
	WML	2.694	2.095–3.465 (<.001)
3	PP	1.014	1.008–1.020 (<.001)
	WML	2.694	2.095–3.465 (<.001)

Univariable models by WML grade
Model	Predictor	Low-grade WML		High-grade WML
		HR	95% CI (p)*	HR	95% CI (p)*
1	DBP	1.014	1.000–1.030	1.018	1.000–1.030
2	DBP	1.013	1.000–1.030	1.013	1.000–1.030 (.05)
	DBP2	1.0006	1.000–1.002	1.0009	1.000–1.002 (.007)
3	SBP	1.011	1.000–1.020 (.014)	1.015	1.010–1.020 (.001)
4	SBP	1.009	0.990–1.020	1.009	0.990–1.020
	SBP2	1.000	1.000–1.000	1.000	1.000–1.000

Notes: DBP = diastolic blood pressure centered at 72 mmHg, SBP = systolic blood pressure centered at 120 mmHg, PP = pulse pressure centered at 48 mmHg, DBP² = quadratic term for diastolic blood pressure, SBP² = quadratic term for systolic blood pressure. CI = confidence interval; HR = hazard ratios; WML = white matter lesions.

^*p Value given in parenthesis is two sided and specified when ≤0.05.