Table 1.
Mean values of interferon gamma (IFN-γ) response of volunteers on stimulation with LSP and peptides restricted to different HLA alleles from the N- and C-terminal regions of the Plasmodium vivax circumsporozite (CS) protein
| Volunteers | HLA class I typing | N* | Pv6† | Pv8‡ | ||||
|---|---|---|---|---|---|---|---|---|
| 1 | A2,24 | B35,38 | 9 (26) | 16 (30) | 6 (13) | |||
| 2 | A24,0 | B40,57 | 11 (25) | 30 (85) | 38 (107) | |||
| 3 | A1,23 | B15,48 | 24 (29) | 15 (32) | 4 (7) | |||
| 4 | A24,0 | B35,40 | 73 (120) | 26 (29) | 51 (132) | |||
| 5 | A24,32 | B8,52 | 0 | 19 (28) | 2 (4) | |||
| 6 | A24,0 | B35,38 | 39 (116) | 25 (51) | 20 (52) | |||
| C§ | Pv1¶ | Pv3¶ | Pv5¶ | Pv7¶ | Pv9‖ | |||
| 8 | A24,29 | B35,38 | 31 (93) | 0 | 22 (66) | 80 (39) | 38 (115) | 0 |
| 9 | A24,0 | B40,57 | 6 (10) | 13 (14) | 12 (25) | 5 (7) | 13 (24) | 7 (16) |
| 10 | A24,0 | B15,48 | 38 (111) | 0 | 0 | 26 (38) | 0 | 51 (65) |
| 11 | A24,29 | B35,38 | 0 | 0 | 3 (9) | 13 (25) | 0 | 0 |
| 12 | A24,5 | B15,44 | 0 | 0 | 34 (102) | 82 (205) | 16 (48) | 16 (47) |
| 13 | A2,24 | B40,57 | 6 (8) | 0 | 0 | 15 (24) | 0 | 1 (13) |
| 14 | A24,0 | B35,38 | 27 (65) | 52 (72) | 31 (50) | 4 (10) | 107 (121) | 201 (208) |
*
N-terminal long synthetic peptide (LSP).
†
HLA-A2 Pv CTL epitope.
‡
HLA-B35 restricted peptide.
§
C-terminal long synthetic peptide (LSP).
¶
HLA-A2 Pv restricted epitodes.
‖
HLA-B53 restricted peptide.