Table 3.
Signifcant regulation of genes involved in the infammatory/immune defense response of infarcted mice.
| Name | Symbol | X | P |
|---|---|---|---|
| Chemokine (c-c motif) ligand 8 | Ccl8 | 9.70 | 0.024 |
| Chemokine (c-c motif) ligand 9 | Ccl9 | 2.31 | 0.040 |
| Chemokine (c-x-c motif) ligand 14 | Cxcl14 | 2.31 | 0.027 |
| Chemokine-like receptor 1 | Cmklr1 | 1.82 | 0.004 |
| Complement component 3 | C3 | 2.68 | 0.015 |
| Gamma-glutamyltransferase-like activity 1 | Ggtla1 | 2.16 | 0.026 |
| Immunity-related gtpase family, m | Irgm | 1.81 | 0.009 |
| Interferon (alpha and beta) receptor 1 | Ifnar1 | 1.51 | 0.016 |
| Interferon activated gene 204 | If204 | 3.21 | 0.000 |
| Interferon activated gene 205 | If205 | 5.06 | 0.001 |
| Interferon consensus sequence binding protein 1 | Icsbp1 | 1.55 | 0.025 |
| Interferon gamma receptor 1 | Ifngr1 | 2.02 | 0.013 |
| Interferon gamma receptor 2 | Ifngr2 | 2.01 | 0.015 |
| Interferon induced with helicase c domain 1 | Ifh1 | 1.58 | 0.006 |
| Interferon-induced protein 35 | If35 | 1.54 | 0.039 |
| Interferon-stimulated protein | Isg20 | 1.58 | 0.012 |
| Interleukin 1 family, member 9 | Il1f9 | 1.69 | 0.018 |
| Interleukin 1 receptor, type 1 | Il1r1 | 2.53 | 0.024 |
| Interleukin 13 | Il13 | 2.11 | 0.017 |
| Interleukin 13 receptor, alpha 1 | Il13ra1 | 1.93 | 0.005 |
| Interleukin 2 receptor, gamma chain | Il2rg | 1.91 | 0.047 |
| Interleukin 22 receptor, alpha 1 | Il22ra1 | 2.17 | 0.047 |
| Interleukin 6 signal transducer | Il6st | 2.71 | 0.018 |
| Interleukin-1 receptor-associated kinase 1 | Irak1 | 1.57 | 0.038 |
| Interleukin-1 receptor-associated kinase 2 | Irak2 | 3.27 | 0.000 |
| Interleukin-1 receptor-associated kinase 3 | Irak3 | 2.95 | 0.030 |
| Interleukin-1 receptor-associated kinase 4 | Irak4 | 1.61 | 0.015 |
| Nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 4 | Nfatc4 | 1.94 | 0.015 |
| Toll interacting protein | Tollip | 1.50 | 0.048 |
| Toll-like receptor 2 | Tlr2 | 1.65 | 0.005 |
| Toll-like receptor 4 | Tlr4 | 3.15 | 0.001 |
| Tumor necrosis factor receptor superfamily, member 10b | Tnfrsf10b | 1.68 | 0.043 |
| Tumor necrosis factor receptor superfamily, member 12a | Tnfrsf12a | 2.37 | 0.001 |
| Tumor necrosis factor receptor superfamily, member 19-like | Tnfrsf19l | 1.61 | 0.010 |
| Tumor necrosis factor receptor superfamily, member 1a | Tnfrsf1a | 1.52 | 0.008 |
| Tumor necrosis factor receptor superfamily, member 1b | Tnfrsf1b | 1.92 | 0.006 |
| Tumor necrosis factor receptor superfamily, member 22 | Tnfrsf22 | 1.80 | 0.039 |
| Tumor necrosis factor receptor superfamily, member 25 | Tnfrsf25 | 1.80 | 0.025 |
X = fold difference (negative for down-regulation). The Student heteroscedastic t-test was used for the comparison of heart failure with control.