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. Author manuscript; available in PMC: 2011 Feb 2.
Published in final edited form as: Lancet. 1981 Feb 28;1(8218):470–471. doi: 10.1016/s0140-6736(81)91851-1

TABLE I. Nephrotoxicity* from Cyclosporin A Found in Liver Transplant Patients.

Patient Time of max. toxicity after transplant (days) Max. serum creatinine (μmol/l) CyA dose (mg/kg) Non-toxic CyA dose (mg/kg)
1 22 221 13.0 11.0
4 22 548 17.5 8.2
5 17 248 17.5 14.0
6 13 424 17.5 7.2
7 15 221 17.5 8.7
9 (a) 13 813 20.0 7.5
9 (b) 41 274 11.0 7.5
Mean±SE 17±3.8† 393±206 16.3±2.9 9.2±2.3
*

Nephrotoxicity defined as a serum creatinine>175 μmol/l.

†

Excluding 9 (b).