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. Author manuscript; available in PMC: 2011 Feb 2.
Published in final edited form as: Lancet. 1981 Feb 28;1(8218):470–471. doi: 10.1016/s0140-6736(81)91851-1

TABLE II. Nephrotoxicity in Renal Transplanted Patients from Cyclosporin A Recorded as Kidney Function Just Before Discontinuing Cyclosporin A.

Patient Time of change to azathioprine alter transplant (mo) Serum-creatinine on CyA (μmol/l) CyA dose (mg/kg) Serum creatinine on azathioprine (μmol/l)* Indications for change of immunosuppression
3 8 274 10.7 133 Suspected nephrotoxicity plus hepatoxicity (bilirubin 50 μmol/l)†
9 6 318 7.0 159 Suspected nephrotoxicity
12 4 407 7.0 230 Suspected nephrotoxicity
21 5 318 5.2 Kidney loss Suspected nephrotoxicity
*

Kidney function for patients on azathioprine recorded when the function had reached a steady state. Steroid treatment remained unchanged during this period (prednisone 10–20 mg/day).

‡

Patient 3 had a normal liver function within 2 weeks.