Figure 4.
HDAC inhibition enhances memory for the object itself in CBPKIX/KIX homozygous knock-in mice. (A) Schematic of OLM task. Letters (A, B, C) in the boxes indicate objects. Gray arrow indicates a moved object compared to the training. (B) CBPKIX/KIX mice and wild-type littermates received 10-min training period followed immediately by i.p. injection of either NaBut (1.2 g/kg in water) or vehicle (water). During the retention test, in which the familiar object is in a different location (gray arrow), wild-type mice exhibited no preference for the novel object regardless of treatment. In contrast, CBPKIX/KIX mice displayed a poor preference for the novel object, which was significantly enhanced by NaBut treatment. **, P < 0.01; ***, P < 0.001. Numbers inside bars indicate sample size (n).