Kinetics of mPGES-1 expression. The bold black line shows the gene expression of mPGES-1. The number of footpads used in the analysis ranged from 12–16 per data point. Their RNA expression was normalized to 18S RNA, and then, the values in each experiment are normalized to the respective normal control to deduce the relative units. The results from three independent repeats, each showing a similar pattern, are averaged, tested for normality and compared by ANOVA, followed by Bonferroni procedure. MPGES-1 in normal footpads is only different from inflamed footpads (p < 0.001) but not when compared with the resolving footpads (p > 0.99). The kinetics of COX-2 expression (gray line) has been included for comparison.