Table 3.
Sensitivity analysis of variables contributing to the costs of drug-related morbidity and mortality model
| Sensitivity analyses | Limit | Description of rate used* | Resulting Parameter Size | Resulting ADEs (thousands) | Resulting costs of ADEs (million €) | |
|---|---|---|---|---|---|---|
| 1. | Comparison of effect of German hospitalisation rates on model | Lower (base case) | Schneeweiss [8]: 2.4% of medical admissions | Hospitalisations**: 139,405 | 2,140 | 816 |
| Upper | Dormann [7] : 3.8% of medical admissions | Hospitalisations: | 3,388 | 1,292 | ||
| Total: 220,724 | ||||||
| (Death: 4,684) | ||||||
| 2. | Variation in rate of physician visits according to literature*** | Lower | 3.5% [28] (total = 1,731,649) |
Physician visits: 635,008 | 2,375 | 828 |
| Additional treatment: 1,096,640 | ||||||
| Upper | 22% [29] (total = 11,075,753) |
Physician visits: 4,061,560 | 11,719 | 1,291 | ||
| Additional treatment: 7,014,193 | ||||||
| 3. | Variation in emergency department visits according to literature | Lower | 0.9% [28] | 432,912 | 2,364 | 914 |
| Upper | 3.0% [29] | 1,499,696 | 3,431 | 1,380 | ||
| 4. | Change in only hospital admissions according to literature | Lower | 0.5% [28] | Hospitalisations: 246,603 | 2,252 | 1,205 |
| Deaths: 5346 | ||||||
| Upper | 4.2% [29] | Hospitalisations: 2,051,109 | 4,096 | 7,569 | ||
| Deaths: 44,466 |
*Rates refer to percentage of patients taking medications unless stated otherwise; **Equal to base case calculations; ***1/3 calculated as only physician visit and 2/3 rds with additional treatment)