Table 2.
Bioinformatic results for proteins involved in the RanGTP-dependent RNA export pathways
| Opisthokonta | Amo | Plantae | Chromalveolata | Excavata | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Queries | Hsa | Cin | Dme | Cel | Mbr | Cgl | Afu | Spo | Cne | Ecu | Ddi | Ehi | Ath | Osa | Pop | Ppa | Cre | Vca | Cme | Ehu | Tpa | Pfa | Tgo | Cpa | Pte | Tth | Ptr | Tps | Pin | Lma | Tbr | Ngr | Gla | Tva | |
| Hsa_RAN | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Sce_Gsp1p | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Hsa_Ranbp1 | 1 | 2 | 4 | 4 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 1 | 1 | 2 | 4 | 2 | 4 | 2 | 4 | 4 | 2 | 2 | 2 | 2 | 2 | 2 | 1 | 3 | 2 | 2 | 2 | 2 | |
| Sce_Yrb1p | 2 | 2 | 4 | 4 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 4 | 2 | 4 | 2 | 4 | 4 | 1 | 2 | 2 | 2 | 2 | 2 | 2 | 3 | 2 | 2 | 3 | 2 | |
| Ran cycle proteins | |||||||||||||||||||||||||||||||||||
| Hsa_RCC1 | 1 | 1 | 4 | 4 | 4 | 3 | 3 | 3 | 3 | 3 | 4 | 4 | 3 | 3 | 2 | 3 | 3 | 4 | 2 | 4 | 4 | 3 | 4 | 4 | 4 | 4 | 4 | 3 | 2 | 4 | 4 | 4 | NC | 4 | |
| Sce_Srm1p | 3 | 3 | 3 | 3 | 3 | 1 | 1 | 2 | 2 | 3 | 3 | NC | 3 | 3 | 3 | 3 | 3 | 3 | 4 | 3 | 4 | 4 | 4 | 4 | 3 | 4 | 4 | 3 | 3 | 4 | 4 | 3 | NC | 4 | |
| Hsa_RANGAP | 1 | 1 | 2 | 4 | 3 | 4 | 3 | 4 | 4 | 4 | 3 | NC | 3 | 3 | 3 | 3 | 4 | 4 | 3 | 4 | NC | NC | NC | NC | 4 | 4 | 3 | 4 | 4 | 3 | 4 | 3 | 4 | 3 | |
| Sce_Rna1 | 4 | 4 | 4 | 4 | 4 | 1 | 1 | 1 | 2 | 3 | 4 | NC | 4 | 4 | 4 | 4 | NC | 3 | NC | 4 | NC | NC | NC | NC | 3 | 3 | NC | NC | 4 | NC | NC | NC | NC | NC | |
| Hsa_XPO5 | 1 | 3 | 2 | 5 | 3 | 3 | 3 | 3 | 5 | 5 | 3 | NC | 3 | 3 | 5 | 3 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | NC | NC | 5 | 5 | 3 | 5 | 5 | 3 | NC | 5 | |
| Sce_Msn5p | 3 | 5 | NC | NC | 3 | 1 | 3 | 3 | NC | NC | 3 | NC | NC | NC | NC | 4 | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | 3 | NC | NC | 4 | NC | NC | |
|
Exportins |
Hsa_Xpot | 1 | 1 | 4 | 3 | 3 | 2 | 3 | 2 | 3 | NC | 2 | 5 | 2 | 3 | 2 | 2 | NC | NC | 3 | 4 | NC | 4 | NC | 5 | NC | NC | 3 | 3 | 3 | 3 | 3 | 4 | 5 | 5 |
| Sce_Los1p | 3 | 3 | NC | 3 | 4 | 1 | 3 | 3 | 3 | NC | 3 | 5 | 3 | 4 | 3 | 3 | NC | NC | NC | NC | NC | NC | NC | 5 | NC | NC | NC | NC | 3 | 5 | 4 | 4 | NC | NC | |
| Hsa_XPO1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 1 | 4 | 2 | 1 | 1 | 1 | 2 | 2 | 1 | 4 | 3 | |
| Sce_Crm1p | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 4 | 2 | 1 | 1 | 1 | 3 | 2 | 1 | 4 | 3 | |
| Hsa_EEFIA | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Sce_Tef2p | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| Hsa_CBP20 | 1 | 1 | 1 | 1 | 4 | 4 | 2 | 1 | 2 | 2 | 4 | 2 | 4 | 4 | 4 | 2 | 1 | 4 | 1 | 4 | 4 | 4 | 4 | 4 | 1 | 4 | 2 | 2 | 4 | 1 | 2 | 4 | NC | 1 | |
| Sce_Cbc2p | 3 | 3 | 3 | 2 | 5 | 1 | 2 | 2 | 3 | 3 | 3 | 3 | 2 | 2 | 2 | 4 | 3 | 4 | 4 | 2 | 2 | 3 | 4 | 3 | 3 | 3 | 4 | 4 | 4 | 2 | 1 | 4 | NC | 2 | |
| Hsa_CBP80 | 1 | 1 | 1 | 2 | NC | 3 | 3 | 3 | 3 | NC | 2 | NC | 2 | 2 | 2 | 2 | 4 | 4 | 4 | 3 | NC | NC | 4 | NC | 3 | NC | NC | NC | 3 | NC | NC | 3 | NC | NC | |
| Sce_Sto1p | 4 | 5 | 3 | 3 | NC | 1 | 3 | 4 | 3 | NC | 4 | NC | 4 | 4 | 4 | 4 | 5 | 5 | 5 | NC | NC | NC | NC | NC | NC | NC | NC | NC | 4 | NC | NC | NC | NC | NC | |
| Hsa_PHAX | 1 | 3 | 2 | 4 | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | 5 | 5 | NC | 5 | 5 | NC | NC | NC | NC | 5 | NC | NC | NC | NC | NC | |
| Sce-no ortholog | |||||||||||||||||||||||||||||||||||
| Additional export factors | |||||||||||||||||||||||||||||||||||
| Hsa_NMD3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 4 | 1 | 1 | 1 | 2 | 4 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | |
| Sce_Nmd3p | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 1 | 1 | 1 | 1 | 4 | 1 | 1 | 1 | 2 | 4 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | |
| Hsa_ZNF622 | 1 | 1 | 2 | 3 | 2 | 3 | 2 | 2 | 2 | NC | 2 | 2 | 2 | 3 | 2 | 2 | 4 | 3 | 3 | 4 | 4 | 3 | 4 | 4 | 4 | 2 | 3 | 3 | 2 | 3 | 4 | NC | 3 | 4 | |
| Sce_Rei1p | 3 | 2 | 2 | 2 | 2 | 1 | 3 | 2 | 2 | NC | 2 | 3 | 2 | 2 | 3 | 2 | 3 | 4 | 3 | 4 | 3 | 5 | 5 | 3 | 3 | 2 | 2 | 4 | 2 | 3 | 3 | NC | 2 | 3 | |
| Hsa-no ortholog | |||||||||||||||||||||||||||||||||||
| Sce_Arx1p | 4 | 4 | 4 | 4 | 4 | 1 | 4 | 3 | NC | NC | 4 | 4 | 4 | 4 | 4 | 4 | 5 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 5 | 4 | 4 | 4 | 4 | 4 | 4 | NC | NC | |
| Hsa-no ortholog | |||||||||||||||||||||||||||||||||||
| Sce_Alb1p | NC | NC | NC | NC | NC | 1 | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | NC | |
Results were ranked into 5 categories (1-5; with 1 being the most conserved). NC (Not Classified). We present results for a representative subset of species in here, and full results are presented in Table S2 (Additional File 1)