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. 2011 Jan 21;8:31. doi: 10.1186/1743-422X-8-31

Table 5.

Single-dose 2mH9N2:6WF10att in-ovo vaccination study in chickens challenged with low-pathogenic H9N2 (WF10) at 2 and 6 weeks post-hatching

Vaccine dose (EID50)/embryo age (days) # positive HI/total # before challenge Age (in weeks) at time of challenge # Shedding virus/total # in swabs (log10TCID50/ml ± SD)

Tracheal # positive HI/total # at 14 dpi

3 dpc 5 dpc 7 dpc
0 (Mock) 0/7 2 7/7 (2.7 ± 0.6) 7/7 (2.5 ± 0.3) 0/7 7/7 (217)
106, 18 3/5 (14) 2 2/5 (2.2 ± 0.2) 2/5 (2.3 ± 0.4) 0/5 5/5 (192)
106, 19 6/7 (32) 2 1/7 (2.5) 0/7 0/7 7/7 (286)
107, 19 3/4 (32) 2 1/4 (2.3) 0/4 0/4 4/4 (260)

0 (Mock) 0/7 6 7/7 (2.5 ± 0.3) 7/7 (2.5 ± 0.2) 0/7 7/7 (320)
106, 18 2/5 (30) 6 3/5 (2.6 ± 0.7) 3/5 (2.2 ± 0.9) 0/5 5/5 (224)
106, 19 5/7 (71) 6 2/7 (2.4 ± 0.5) 0/7 0/7 7/7 (446)
107, 19 3/3 (67) 6 0/3 0/3 0/3 3/3 (227)