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. Author manuscript; available in PMC: 2011 Feb 2.
Published in final edited form as: J Cell Physiol. 2008 Jul;216(1):29–37. doi: 10.1002/jcp.21426

Figure 1. TG100572 inhibits VEGF signaling and induces apoptosis in proliferating vascular endothelial cells.

Figure 1

(A) Endothelial cells cultured in the absence of VEGF (Control), in the presence of VEGF, or in the presence of both VEGF and TG100572 were processed for Western blot detection of phosphorylated Erk1/2 (or total STAT3 as a loading control). (B) Endothelial cells cultured under either proliferating (low density/high serum) or non-proliferating (high density/low serum) conditions were exposed to TG100572 at the indicated concentrations for 24 hr, after which genomic DNA was extracted and resolved on agarose gels in order to visualize DNA laddering indicative of apoptosis.