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. Author manuscript; available in PMC: 2011 Feb 2.
Published in final edited form as: J Cell Physiol. 2008 Jul;216(1):29–37. doi: 10.1002/jcp.21426

Figure 4. Topical delivery of TG100801 in a murine model of choroidal neovascularlization (CNV).

Figure 4

Laser-induced rupture of Bruch’s membrane was performed in C57BL/6 mice, after which animals were dosed topically twice a day with either TG100801 (1% or 0.6% formulations) or vehicle. After 14 days, animals were perfused with FITC-dextran and choroidal whole mounts were photographed for measurement of CNV area by computerized image analysis. (A–C) Representative fluorescent photomicrographs taken from the three treatment groups (A= vehicle, B= 0.6% TG100801, C= 1% TG100801), with fluorescence of the CNV highlighted in red. (D) CNV area graph (data shown as means ± SEM, n= 24 lesion sites; * 1% TG100801 and vehicle groups differ with P= 0.036).