Skip to main content
. Author manuscript; available in PMC: 2011 Feb 2.
Published in final edited form as: J Cell Physiol. 2008 Jul;216(1):29–37. doi: 10.1002/jcp.21426

Table 1.

Kinase inhibitory profile of TG100572

Kinase Family Kinase IC50 (nM)
Receptor tyrosine kinases VEGFR1 2
VEGFR2 7
FGFR1 2
FGFR2 16
PDGFRβ 13
Src family kinases Fgr 5
Fyn 0.5
Hck 6
Lck 0.1
Lyn 0.4
Src 1
Yes 0.2

The ability of TG100572 to inhibit receptor tyrosine kinases and Src kinase activity was determined in kinase assays as described in Methods. The mean concentrations at which half of maximal inhibition occurred (IC50) were calculated from 3 independent experiments.