Table 2. Association of multiple sclerosis with rs391745 located near HERV-Fc1.

Cohort	Status	C-allele carriers	Non-carriers	Fraction C-allele	OR (CI95)	P (2-sided)
				carriers	for carriers
2	Cases	79	246	0.24	2.29 (1.60–3.28)	4*10−6
	Controls	68	485	0.12
3	Cases	99	407	0.20	1.43 (1.09–1.89)	0.010
	Controls	165	972	0.15
4	Cases	35	196	0.15	1.01 (0.64–1.59)	0.97
	Controls	59	333	0.15
2+3+4	Cases	213	849	0.20	1.54 (1.27–1.87)	1.3*10−5
	Controls	292	1790	0.14		F: 6.4*10−6

The p-values were calculated from the numbers of carriers and non-carriers using Pearson's Chi-square test. The p-value for all 3 groups marked F was calculated from the individual p-values using Fisher's formula.