Table 4.

Sensitivity, specificity, positive and negative predictive value and area under curve for all adherence measures in predicting MEMS adherence >95%

Measure	AUC	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
VAS > 95%	0.60	100	13	11	100
VAS > 80%		100	5	10	100
3DR > 95%	0.57	100	10	10	100
3DR > 80%		100	5	10	100
RS > 95%	0.56	100	13	11	100
RS > 80%		100	3	10	100
PR > 95%	0.49	100	10	10	100
PR > 80%		100	0	9	–
VAS + 3DR	0.62	–
3DR + RS	0.59	–
VAS + RS	0.57	–
VAS + PR	0.56	–
3DR + PR	0.52	–
RS + PR	0.48	–
VAS + 3DR + RS	0.60	–
VAS + 3DR + PR	0.58	–
3DR + PR + RS	0.53	–
VAS + PR + RS	0.52	–

The AUC was calculated by using continuous measures, while sensitivity, specificity, PPV and NPV were calculated for the above listed cut-points

AUC Area under curve, MEMS Medication event monitoring system, VAS Visual analogue scale, 3DR 3-Day recall based on PACTG-questionnaire, PR Pharmacy refill, RS Measure of returned syrup, PPV Positive predictive value, NPV Negative predictive value