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. Author manuscript; available in PMC: 2012 Jan 12.
Published in final edited form as: Structure. 2011 Jan 12;19(1):37–44. doi: 10.1016/j.str.2010.11.008

Figure 3. Perturbations in HDX data for CAR and RXR LBDs.

Figure 3

Cartoon rendition of percent reduction in HDX of ligand bound CAR:RXR heterodimer complex relative to unliganded receptor. Increasing protections from deuterium exchange are represented as color gradient from light to dark blue as shown. TCPOBOP is shown as an orange space-filled model. A. CAR portion of CAR(TCPOBOP):RXR (76 peptides). B. RXR portion of CAR(TCPOBOP):RXR (84 peptides). C. CAR portion of the CAR(meclizine):RXR (76 peptides). D. Residues within the encircled region in the unliganded CAR LBD model are mutated and tested for activity. See also Figure S3.