Table 1.
Values for the kinetic parameters used in the model. Other non-kinetic model parameters are p = q = 0.4, ω = 0.1, n = 2n* = 10, f = 0.01, σ = 0.1 and k = 10k0 = 30. The amounts of cellular resources are Z = 105, Y = 105, C0 = 104 and R0 = 104 molecules. In the case of a virus encoding a VSR, the corresponding binding constant (ΓC, ΓI or ΓR) takes the value of Γ. The cell volume is assumed ∼ 10−13 l, then 1 nM ∼ 100 molecules.
| parameter | value | value in the literature |
|---|---|---|
| α | 10 h−1 | 1.7 h−1 for HCV [46] |
| μ | 10 h−1 | 10 h−1 for HCV [46] |
| β | 10 h−1 | 10 h−1 [39,40] |
| δ | 10 h−1 | 228 h−1in vitro for E. coli [59] |
| ρ | 1 h−1 | ∼5 h−1 [39,40] |
| υ | 25 h−1 | 25 h−1in vitro for Drosophila melanogaster [60] |
| λ | 0.1 h−1 | ∼100 M−1 h−1 for nucleation [61] |
| γ | 10 h−1 | ∼105 M−1 h−1 for elongation [61] |
| κS | 0.1 h−1 | 0.5 h−1 [39,40] |
| κI | 1 h−1 | 2 h−1 [39,40] |
| κD | 0.01 h−1 | 0.06 h−1 for HCV [46] |
| κP | 0.01 h−1 | 0.01 h−1 [62] |
| KP | 104 molecules | 225 nM in vitro for TBSV [63] |
| KR | 103 molecules | 8 nM in vitro for D. melanogaster [60] |
| KZ | 104 molecules | 260 nM in vitro [64] |
| KC | 105 molecules | 3780 nM [61] |
| KD | 105 molecules | 335 nM in vitro for E. coli [59] |
| KI | 105 molecules | ∼1000 molecules [39,40] |
| Γ | 103 molecules | 10–1000 nM in vitro p19, p21 and HC-Pro [65] |