Skip to main content
. Author manuscript; available in PMC: 2012 Jan 15.
Published in final edited form as: Eur J Pharmacol. 2010 Oct 27;650(2-3):596–604. doi: 10.1016/j.ejphar.2010.10.045

Figure 1.

Figure 1

Systemic injections of scopolamine dose-dependently attenuate cocaine priming-induced reinstatement of drug seeking. (A) Total numbers of responses (mean±S.E.M.) on the active and inactive levers during the reinstatement session following systemic injection of vehicle (n=11), 0.5 (n=10) and 5.0 (n=7) mg/kg scopolamine and a subsequent priming injection of cocaine (10 mg/kg, i.p.). *P<0.05 for active lever responding between vehicle- and 5.0 mg/kg scopolamine-treated animals. (B) The time courses of active lever responses (mean±S.E.M.) for subjects that received either vehicle or 5.0 mg/kg scopolamine prior to a priming injection of cocaine. (C) Total active lever responses (mean±S.E.M.) during a 1-h sucrose reinstatement session for animals treated with vehicle (n=5) or 5.0 μg scopolamine (n=7). There was no significant difference between treatments on sucrose-seeking behavior (un-paired t-test, P<0.23).