Figure 4.

Selective reduction in LEPRb proteins in somatotropes. Counts of cells labeled for LEPRb and/or the pituitary hormone. Each stacked bar represents the percentages of each cell type in the pituitary population and only percentages of GH cells are reduced in the deletion mutant population. (P < 0.001) (star). There are no significant changes in the percentages of any other cell type. The hatched regions in each bar, representing the proportion of each cell type that expresses LEPRb, show a significant reduction in expression of LEPRb only by somatotropes (P < 0.001, asterisk) in deletion mutants but no change in expression of leptin receptors by other cell types.