Figure 7.

Weight gain in deletion mutant mice. A and B, Weanling (w; 21 d) and young growing mice show no differences when deletion mutant and littermate controls are compared. By 4 months of age, deletion mutant, homozygous males weighed significantly more than their age-matched controls, and this significant difference continued throughout their life (differences at 4–7 and 11 months, P < 0.001; at 8–9 months, P = 0.007; 10 months, P = 0.005; 12 and 13 months, P = 0.002; Student’s t test). Females do not exhibit significant weight gains over age-matched controls until they are 6.5 months old (P = 0.017). The differences are significant from 7 to 9 months of age (7 months, P = 0.02; 8 months, P = 0.015; 9 months, P = 0.038) after which the females in this F3 generation lost weight and the average weights were not different from those of the age-matched controls. Star, Significantly different from controls.