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. 2010 Aug 10;2(1):e2010022. doi: 10.4084/MJHID.2010.022

Table 7.

National Institute of Allergy and Infectious Diseases/National Institute of Mental Health’s modifications of the Centers for Disease Control’s case definition of the chronic fatigue syndrome (from Klonoff 73).

Exclusion
  1. Psychiatric disorders
    1. Psychoses
      1. Psychotic depression
      2. Bipolar disorder
      3. Schizophrenia
    2. Substance abuse
  2. Postinfectious fatigue (must include A, B and C)
    1. Establishment of a definite etiology
    2. An etiologic agent known to regularly produce chronic active infection
    3. A clinical picture compatible with ongoing active infection
      1. Chronic hepatitis B or C with active liver disease
      2. Infection with human immunodeficiency virus
      3. Lyme disease (inadequately treated)
      4. Tuberculosis
Inclusion (in patients who otherwise meet the Centers for Disease Control’case definition)

  1. Fibromyalgia

  2. Postinfectious fatigue
    1. Lyme disease with persistent fatigue after appropriate antibiotic therapy
    2. Brucellosis with persistent fatigue after appropriate antibiotic therapy
    3. Acute infectious mononucleosis (documented) followed by chronic debilitating fatigue
    4. Acute cytomegalovirus infection
    5. Acute toxoplasmosis (adequately treated)

  3. Nonpsycotic depression

  4. Somatoform disorders

  5. Generalized anxiety disorder/panic disorder