Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Dec 20;1(1):e2009024. doi: 10.4084/MJHID.2009.024

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 1. — Schematic diagram of the ion transport pathways involved in sickle cell dehydration and action sites of potential therapeutic blockers: Ca²⁺activated K⁺ channel (Gardos channel, KCNN4): Clotrimazole (CLT) and ICA-17043; K-Cl cotransport (KCC1/3/4): Magnesium (Mg) Pidolate; Deoxygenation-induced pathway: Dipyridamole; Anion conductive pathway: NS3623. Deoxygenation induces Hb S polymerization and sickling, with associated increased membrane permeability and abnormal function of different ion transport pathways, resulting in K⁺, Cl⁻ and water loss and red cell dehydration (modified from De Franceschi L et al. Haematologica 89: 348, 2004).