Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Nov 15;1(2):e2009012. doi: 10.4084/MJHID.2009.012

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 3. — Promoter switch in latent EBV episomes: After initial EBV infection of B cells in vitro, Wp (a promoter located to the BamHI W fragment of the EBV genome) is switched on. A giant transcript coding for 6 nuclear antigens (EBNA1-6) is generated but the activity of Wp is transient. The transactivator protein EBNA2 and the EBNA1-bound oriP enhancer may contribute to switching on Cp, a B lymphoblast specific promoter. Burkitt’s lymphoma (BL) cells use a different promoter, Qp, to generate a transcript for EBNA1 only. In vitro cultivated BL cells may switch from Qp to Cp (arrow to the left). This promoter switch results in a phenotypic drift (from memory B cell to activated B cell phenotype). A Cp to Qp switch has been predicted but never observed (broken arrow) (see Niller et al.¹³).