Table 4.
Cellular genes silenced by promoter hypermethylation in EBV-associated lymphomas and derived cell lines. For detailed discussion see Niller et al.97
| Gene | Lymphoma | ||
|---|---|---|---|
| BL | HD | Iatrogenic/AIDS-associated | |
| ABF1 | + | − | |
| BCL2-family (proapoptotic members) | + | ||
| BCMA | + | ||
| BOB.1/OBF.1 | + | ||
| CHK2 kinase | + | ||
| Cyclin D2 | + | ||
| CD19 | + | ||
| CD20 | + | ||
| CD79B | + | ||
| CD59/HRF20 | + | ||
| DAPK | + | ± | + |
| DLC1 | + | ± | |
| FHIT | + | ||
| GADD25G | + | ||
| GSTP1 | + | ||
| LCK | + | ||
| MAPK10/JNK3 | + | ± | |
| O6-methylguanine-DNA MTase | + | ||
| p16/CDK4A | + | ± | − |
| p15/CDK4B | + | ± | − |
| p57/KIP2 | + | ||
| p73 | + | ||
| PCDH10 | + | + | |
| PLK2 | + | ||
| PU.1 | + | ||
| PTPN13/FAP1 | + | ||
| RASSF1A | − | + | − |
| SYK | + | ||
| WNT5A | + | ||
BL: Burkitt’s lymphoma; HD: Hodgkin’s disease; iatrogenic lymphomas include post-transplant lymphoproliferative disorders (PTLDs) and methotrexate-related lymphomas.
Symbols: frequent inactivation by promoter methylation, +; infrequent inactivation by promoter methylation, −/+; typically unmethylated promoter, −.