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GEF activity of Epac2 in the presence of various concentrations of TLB. The rates of nucleotide exchange of Mant-GDP by GDP were measured as a time-dependent decrease in fluorescence intensity in the presence of various concentrations of TLB as indicated. The arrow indicates the addition of cAMP at a final concentration of 300 μM. TLB, Tolbutamide [1-butyl-3-(4-methylphenylsulfonyl)urea].
