Table 1.

Concentrations of Cho, Cr and NAA as corrected using empirical T₁ and T₂ relaxation times and expressing the (mean±SD) in mM by QUEST and LCMODEL. Statistics were evaluated using Tukey’s honestly significant difference tests.

Methods	Metabolite	Group	Concentrations	Population	G3	G4
QUEST	Cho	Normal	2.3±0.5	N=20
		G3	2.9±0.9	N=5		P<0.01
		G4	1.9±0.5	N=10	P<0.01
	Cr	Normal	8.9±1.6	N=20		P<0.001
		G3	9.1±2.4	N=5		P<0.005
		G4	6.0±0.9	N=10	P<0.005
	NAA	Normal	12.4±2.1	N=20	P<0.001	P<0.001
		G3	6.8±1.5	N=5
		G4	6.3±1.6	N=10
LCModel	Cho	Normal	2.0±0.5	N=20
		G3	2.3±0.6	N=5
		G4	1.7±0.6	N=10
	Cr	Normal	8.4±1.5	N=20		P=0.001
		G3	8.6±2.6	N=5		P<0.001
		G4	5.8±1.1	N=10	P<0.001
	NAA	Normal	12.5±2.1	N=20	P<0.001	P<0.001
		G3	5.5±1.5	N=5
		G4	6.6±2.2	N=10

N=number of patients