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. 2011 Jan 18;108(5):2004–2009. doi: 10.1073/pnas.1011982108

Fig. 4.

Fig. 4.

Deletion of the HDACs Hos3 and Hos2 affects spliceosome dynamics downstream of U2 snRNP recruitment. (A) Bar graph depicting the cotranscriptional recruitment of U5 snRNP (Sun114-HA) to DBP2 in the presence and absence of Hos3 and Hos2 (Left). Light gray bars represent the occupancy of Snu114-HA in a wild-type background and the dark gray bars represent Snu114-HA recruitment when HOS3 and HOS2 are deleted. Occupancy is measured as fold-accumulation over the nontranscribed control. Bar graph represents the recruitment of Prp19-HA to DBP2 in the presence and absence of Hos3 and Hos2 (Right). Light gray bars represent wild-type and dark gray bars represent the hos3Δ, hos2Δ double mutant strain. (B) Bar graph depicting the cotranscriptional recruitment of U5 snRNP (Snu114-HA) and Prp19-HA to ECM33 in the presence and absence of Hos3 and Hos2 (Left and Right, respectively). Data are represented as in A. Graphs represent the average of at least three independent experiments.