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. 2011 Jan 11;108(5):1897–1902. doi: 10.1073/pnas.1019059108

Fig. 4.

Fig. 4.

RIG-I induction alone inhibits proliferation of AML cells both in vitro and in vivo. (A) Flow cytometric assays show that RIG-I induction triggers U937 cells to express CD11b and to undergo cell cycle arrest and cell death. (B) Flow cytometric assays show that Rig-I transduction triggers APL cells to undergo cell cycle arrest and cell death. Rig-I transduction induces Stat1 activation (C) and ISG expression (D) in mouse APL cells, as measured by Western blotting and real-time PCR assays (n = 3, mean ± SD; *P < 0.05). (E) Rig-I transduction inhibits the in vivo proliferation of the inoculated GFP+ c-Kit+ APL BM cells (n = 3, mean ± SD; *P < 0.05). The percentage of GFP+ cells in mouse peripheral blood was monitored by flow cytometry at the indicated time points. (F) Survival curves of the normal recipients receiving either empty vector- or Rig-I–transduced c-Kit+ APL BM cells.