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GRP blockade abrogates O3-induced AHR and inflammation. (A and B) PFTs on BALB/C mice exposed to O3 or FA, using the flexiVent system. Mice given 77427 (A) or 2A11 (B) before O3 had decreased airway resistance at higher MCh doses (25 or 100 mg/mL). *P < 0.01, **P < 0.05, n = 8. (C and D) Pretreatment with 77427 (C) or 2A11(D) reduced numbers of BAL macrophages and PMN induced by O3.*P < 0.01, n = 8.
