Fig. 4.

CUX1 transcriptional targets are highly expressed in breast tumor subtypes with poor prognosis and identify a subset of luminal tumors with poor outcome. (A) List of 29 CUX1 transcriptional targets used in expression analysis. Targets include 20 genes validated in Table 1 (but excludes ROD, which is absent from published microarray datasets), plus eight previously characterized DNA replication genes whose expression is strongly stimulated by p110 CUX1 and CTSL1 (12). (B) Kaplan-Meier curve displaying significant segregation of good outcome vs. bad outcome patients classified into “low” and “high” groups on the basis of a 29-gene signature. (C) Breakdown and percentage of patients classified into each molecular subtype for “low” and “high” expression groups. (D) Kaplan-Meier curves comparing the outcome of low- and high-expressing groups for patients reported to be ER⁺/LN⁻ and ER⁺/LN⁺. Lower: ER⁺/LN⁻ patients were further classified into luminal A and luminal B subtypes.