Table 3.
Stratified analysis between methotrexate (MTX) use and elevated ATP-binding cassette transporter A1 (ABCA1) and 27-hydroxylase expression in study subjects
| Category | Logistic regression | |||
|---|---|---|---|---|
| Low (≤median) | High (>median) | OR (95% CI) | P value | |
| ABCA1/18S: | ||||
| MTX | ||||
| No (n = 32) | 20 (62.5%) | 12 (37.5%) | 1.00 | |
| Yes (n = 67) | 31 (46%) | 36 (54%) | 1.94 (0.82 to 4.58) | 0.13 |
| 27-Hydroxylase/18S: | ||||
| MTX | ||||
| No (n = 32) | 21 (66%) | 11 (34%) | 1.00 | |
| Yes (n = 67) | 29 (43%) | 38 (57%) | 2.50 (1.04 to 6.01) | 0.038 |
Values represent N (%). Logistic regression results are expressed as OR (95% confidence interval) (n = 99).