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. 2011 Feb 3;6(2):e16588. doi: 10.1371/journal.pone.0016588

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Kostic et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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PLR was measured following stimulation with increasing light intensities from 15 lux to 1500 lux. Each eye was independently and sequentially stimulated with 50 ms white stimuli (represented by vertical bars on the graphs) every 5 s. The pupil contraction was recorded and the diameter was plotted versus the time. (A) The average of 4 pupil responses of 1 month-old WT mice showed that eyes respond to even the lower stimulus tested without a noticeable increase of the amplitude of contraction with increasing intensity of stimuli. (B) The pupil responses from 5 eyes of 4 month-old Rpe65^R91W/R91W mice were averaged and showed a severe loss of sensitivity at this age for Rpe65^R91W/R91W animals. (C) The average pupil response recorded for 6 eyes injected at 1 month of age with LV-GFP shows poor pupil light reflex 3 months post injection. (D) The average pupil response recorded for 4 eyes injected at 1 month of age with LV-RPE65 shows improvement of the pupil light reflex 3 months post injection. Even for the lowest stimuli applied (15 lux), a pupil contraction is evident.