FIG. 3.

Mild fasting-state hyperinsulinemia, hyperglycemia, increased insulin secretion, and impaired glucose tolerance in RIP-Cre/STAT3^lox/lox mice. Fasting-state levels of plasma insulin (A) and glucose (B) were both increased in RIP-Cre/STAT3^lox/lox mice. Insulin secretion of isolated islets from RIP-Cre/STAT3^lox/lox mice was also significantly increased at stimulating glucose concentration (15.8 mM) but not under basal glucose concentration (3.7 mM) (C). RIP-Cre/STAT3^lox/lox mice exhibited reduced glucose tolerance (D), as revealed by delayed glucose disposal at the indicated time points. WT, wild-type STAT3^lox/lox mice; KO, RIP-Cre/STAT3^lox/lox mice. *, P < 0.05; ***, P < 0.0001.