Table 1.

Affinity of FD1-FD12 and cyclosporin A binding to cyclophilin A, and their IC₅₀ values for inhibition of PPIase activity of cyclophilin A and HIV-1 replication.

Compound	Binding to cyclophilinA, KD (M)	IC50 for inhibition of PPIase activity (µM)	% Inhibition of HIV-1 replication	CC50 (µM)
FD1	7.67±0.12×10−5	70.2±3.04	26.7	>100
FD2	6.78±0.08×10−5	72.8±1.12	23.0	>100
FD3	7.33±0.26×10−5	65.7±2.55	29.9	>100
FD4	2.11±0.15×10−5	56.2±0.97	22.5	>100
FD5	6.61±0.09×10−6	14.45±0.67	57.2	14.46±0.59
FD6	9.19±1.03×10−6	21.65±2.20	18.2	41.81±2.52
FD7	3.61±0.25×10−5	43.75±1.15	33.7	73.75±0.67
FD8	8.42±0.13×10−6	18.67±1.74	62.6	40.91±0.59
FD9	1.03±0.16×10−5	34.86±0.76	77.5	54.24±4.96
FD10	5.95±0.24×10−6	6.98±1.39	64.2	65.66±4.77
FD11	4.72±0.27×10−5	53.4±1.63	44.9	71.46±4.13
FD12	3.19±0.22×10−6	3.47±0.92	65.2	69.73±0.75
Cyclosporin A	2.18±0.36×10−7	0.45±0.38	98.9	6.26±0.28