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Putative mechanisms linking 5-LOX and COX pathways to Alzheimer’s disease (AD). 5-LOX could influence AD by producing pro-inflammatory leukotrienes (LTB4 and CysLTs) and anti-inflammatory lipoxins (naturally occurring LHA4 and aspirin-triggered 15-epi-LXA4) and by an interaction with the gamma-secretase complex. Cyclooxygenases could influence AD by acting on arachidonic acid (AA) and producing PGH2 and PGE2 (see text for details).
