Skip to main content
. Author manuscript; available in PMC: 2012 Jan 20.
Published in final edited form as: Cell Host Microbe. 2011 Jan 20;9(1):1–2. doi: 10.1016/j.chom.2011.01.002

Figure 1. PI4KIIIα Is Needed for HCV Replication Complex Assembly.

Figure 1

(A and B) HCV RNA replication is thought to take place within invaginations of an ER-derived membrane. The viral NS3-4A, NS4B, NS5A, and NS5B proteins are all essential for this process (A). NS5A binds and activates PI4KIII, leading to the local production of PI4P (B). One possibility is that PI4P then recruits viral or cellular factors that are essential for forming the replication compartment.