Fig. 5.

Effect of the combination of ATP and ivermectin on the decrease of the [K⁺]_i in murine peritoneal macrophages. Macrophages from WT (upper panel) or P2X₇-KO (lower panel) mice primed for 4 h with 250 ng/mL LPS were loaded with PBFI/AM. After washing, they were incubated in a medium containing 1 mM CaCl₂ but no magnesium, in control conditions or in the presence of 3 μM ivermectin (IVER). Five minutes after the start of the measurement, 10 μM or 1 mM ATP was added to the cuvette. Results are expressed as % of the initial signal and are the means + SEM of four experiments